The Synapse trial compares a 5 day infusion of progesterone to placebo and looks at the patient's neurological outcome. There is preliminary evidence that progesterone may help minimize the secondary injury following severe head trauma.
Cook County Trauma Unit is just one of several international centers studying this drug. To date, over 1000 patients have been enrolled with very few adverse events.
http://cookcountytrauma.blogspot.com/2011/08/do-you-have-patient-with-head-injury.html

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